Nerve Growth Factor and Diabetic Neuropathy
نویسندگان
چکیده
منابع مشابه
Nerve Growth Factor and Diabetic Neuropathy
Neuropathy is one of the most debilitating complications of both type 1 and type 2 diabetes, with estimates of prevalence between 50-90% depending on the means of detection. Diabetic neuropathies are heterogeneous and there is variable involvement of large myelinated fibers and small, thinly myelinated fibers. Many of the neuronal abnormalities in diabetes can be duplicated by experimental depl...
متن کاملNeuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy.
OBJECTIVE Axonal regeneration is defective in both experimental and clinical diabetic neuropathy, contributing to loss of axonal extremities and neuronal dysfunction. The mechanisms behind this failure are not fully understood; however, a deficit in neurotrophic support and signaling has been implicated. RESEARCH DESIGN AND METHODS We investigated the expression of neuritin (also known as can...
متن کاملNerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts.
BACKGROUND Molecular mechanisms regulating the cardiac sensory nervous system remain poorly understood. Cardiac sensory nerve impairment causes silent myocardial ischemia, a main cause of sudden death in diabetes mellitus (DM). The present study focused on the roles of nerve growth factor (NGF) in the regulation of the cardiac sensory nervous system and analyzed the mechanism of silent myocardi...
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OBJECTIVE To assess the relevance of vascular endothelial growth factor (VEGF) in the maintenance of peripheral nerve integrity in diabetic neuropathy we have assessed the expression of VEGF and intra-epidermal nerve fiber density (IENFD) in skin biopsy samples from diabetic patients. RESEARCH DESIGN AND METHODS Fifty-three diabetic patients and 12 nondiabetic control subjects underwent neuro...
متن کاملFacial nerve conduction in diabetic neuropathy.
Diabetes mellitus (DM) has a severe influence on the nervous system and it is more likely to occur on the nerves of the upper and lower extremities than on the cranial nerves. According to the statistics, the incidence of cranial nerve involvement ranges anywhere from 3% to 14%. The aim of this study is to perform facial nerve conduction studies in diabetic patients with peripheral neuropathy, ...
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ژورنال
عنوان ژورنال: Experimental Diabesity Research
سال: 2003
ISSN: 1543-8600,1543-8619
DOI: 10.1155/edr.2003.271